Direct Simulation of the Sedimentation of Elliptic Particles in Oldroyd-B Fluids

Cross stream migration and stable orientations of elliptic particles falling in an Oldroyd-B fluid in a channel are studied. We show that the normal component of the extra stress on a rigid body vanishes; lateral forces and torques are determined by the pressure. Inertia turns the longside of the ellipse across the stream and elasticity turns it along the stream; tilted off-center falling is unstable. There are two critical numbers; elasticity and Mach numbers. When the elasticity number is smaller than critical the fluid is essentially Newtonian with broadside-on falling at the centerline of the channel. For larger elasticity numbers the settling turns the longside of the particle along the stream in the channel center for all velocities below a critical one, identified with a critical Mach number of order one. For larger Mach numbers the ellipse flips into broadside-on falling again. The critical numbers are functions of the channel blockage ratio, the particle aspect ratio and the retardation/relaxation time ratio of the fluid. Two ellipses falling nearby, attract, line-up and straighten-out in a long chain of ellipses with longside vertical, all in a row. Stable, off-center tilting is found for ellipses falling in shear thinning fluids and for cylinders with flat ends in which particles tend align their longest diameter with gravity

EUS-guided portal pressure gradient measurement with a simple novel device: a human pilot study.

Background and aimsPortal hypertension is a serious adverse event of liver cirrhosis. Recently, we developed a simple novel technique for EUS-guided portal pressure gradient (PPG) measurement (PPGM). Our animal studies showed excellent correlation between EUS-PPGM and interventional radiology-acquired PPGM. In this video we demonstrate the results of the first human pilot study of EUS-PPGM in patients with liver disease.MethodsEUS-PPGM was performed by experienced endosonographers using a linear echoendoscope, a 25-gauge FNA needle, and a novel compact manometer. The portal vein and hepatic vein (or inferior vena cava) were targeted by use of a transgastric or transduodenal approach. Feasibility was defined as successful PPGM in each patient. Safety was based on adverse events captured in a postprocedural interview.ResultsTwenty-eight patients underwent EUS-PPGM with 100% technical success and no adverse events. PPG ranged from 1.5 to 19 mm Hg and had excellent correlation with clinical parameters of portal hypertension, including the presence of varices (P = .0002), PH gastropathy (P = .007), and thrombocytopenia (P = .036).ConclusionThis novel technique of EUS-PPGM using a 25-gauge needle and compact manometer is feasible and appears safe. Given the availability of EUS and the simplicity of the manometry setup, EUS-guided PPG may represent a promising breakthrough for procuring indispensable information in the management of patients with liver disease

Direct Simulation of the Motion of Solid Particles in Couette and Poiseuille Flows of Viscoelastic Fluids

This paper reports the results of direct numerical simulation of the motion of a two-dimensional circular cylinder in Couette flow and in Poiseuille flow of an Oldroyd-B fluid. Both neutrally buoyant and non-neutrally buoyant cylinders are considered. The cylinder\u27s motion and the mechanisms which cause the cylinders to migrate are studied. The stable equilibrium position of neutrally buoyant particles varies with inertia, elasticity, shear thinning and the blockage ratio of the channel in both shear flows. Shear thinning promotes the migration of the cylinder to the wall while inertia causes the cylinder to migrate away from the wall. The cylinder moves closer to the wall in a narrower channel. In a Poiseuille flow, the effect of elastic normal stresses is manifested by an attraction toward the nearby wall if the blockage is strong. If the blockage is weak, the normal stresses act through the curvature of the inflow velocity profile and generate a lateral force that points to the centreline. In both cases, the migration of particles is controlled by elastic normal stresses which in the limit of slow flow in two dimensions are compressive and proportional to the square of the shear rate on the body. A slightly buoyant cylinder in Couette flow migrates to an equilibrium position nearer the centreline of the channel in a viscoelastic fluid than in a Newtonian fluid. On the other hand, the same slightly buoyant cylinder in Poiseuille flow moves to a stable position farther away from the centreline of the channel in a viscoelastic fluid than in a Newtonian fluid. Marked effects of shear thinning are documented and discussed

Novel critical point drying (CPD) based preparation and transmission electron microscopy (TEM) imaging of protein specific molecularly imprinted polymers (HydroMIPs)

We report the transmission electron microscopy (TEM) imaging of a hydrogel-based molecularly imprinted polymer (HydroMIP) specific to the template molecule bovine haemoglobin (BHb). A novel critical point drying based sample preparation technique was employed to prepare the molecularly imprinted polymer (MIP) samples in a manner that would facilitate the use of TEM to image the imprinted cavities, and provide an appropriate degree of both magnification and resolution to image polymer architecture in the <10 nm range. For the first time, polymer structure has been detailed that clearly displays molecularly imprinted cavities, ranging from 5-50 nm in size, that correlate (in terms of size) with the protein molecule employed as the imprinting template. The modified critical point drying sample preparation technique used may potentially play a key role in the imaging of all molecularly imprinted polymers, particularly those prepared in the aqueous phase

A very low power and low signal 5 bit 50 M samples/s double sampling pipelined ADC for Monolithic Active Pixel Sensors in high energy physics and biomedical imaging applications

International audienc

A low power and low signal 4 bit 50MS/s double sampling pipelined ADC for Monolithic Active Pixel Sensors

soumis à JINSTA 4 bit very low power and low incoming signal analog to digital converter (ADC) using a double sampling switched capacitor technique, designed for use in CMOS monolithic active pixels sensor readout, has been implemented in 0.35µm CMOS technology. A non-resetting sample and hold stage is integrated to amplify the incoming signal by 4. This first stage compensates both the amplifier offset effect and the input common mode voltage fluctuations. The converter is composed of a 2.5 bit pipeline stage followed by a 2 bit flash stage. This prototype consists of 4 ADC double-channels; each one is sampling at 50MS/s and dissipates only 2.6mW at 3.3V supply voltage. A bias pulsing stage is integrated in the circuit. Therefore, the analog part is switched OFF or ON in less than 1µs. The size for the layout is 80µm*0.9mm. This corresponds to the pitch of 4 pixel columns, each one is 20µm wide

Chalcogenide Glass-on-Graphene Photonics

Two-dimensional (2-D) materials are of tremendous interest to integrated photonics given their singular optical characteristics spanning light emission, modulation, saturable absorption, and nonlinear optics. To harness their optical properties, these atomically thin materials are usually attached onto prefabricated devices via a transfer process. In this paper, we present a new route for 2-D material integration with planar photonics. Central to this approach is the use of chalcogenide glass, a multifunctional material which can be directly deposited and patterned on a wide variety of 2-D materials and can simultaneously function as the light guiding medium, a gate dielectric, and a passivation layer for 2-D materials. Besides claiming improved fabrication yield and throughput compared to the traditional transfer process, our technique also enables unconventional multilayer device geometries optimally designed for enhancing light-matter interactions in the 2-D layers. Capitalizing on this facile integration method, we demonstrate a series of high-performance glass-on-graphene devices including ultra-broadband on-chip polarizers, energy-efficient thermo-optic switches, as well as graphene-based mid-infrared (mid-IR) waveguide-integrated photodetectors and modulators

Generalized Holographic Dark Energy Model

In this paper, the model of holographic Chaplygin gas has been extended to two general cases: first is the case of modified variable Chaplygin gas and secondly of the viscous generalized Chaplygin gas. The dynamics of the model are expressed by the use of scalar fields and the scalar potentials.Comment: 12 pages, to appear in Eur. Phys. J.